Graphical abstract. Credit: DOI: 10.1016/j.brs.2021.07.009

In a first-in-human study, researchers at The Feinstein Institutes for Medical Research elicited the sense of touch through a minimally-invasive electrode brain implant. This research, published recently in Brain Stimulation, has the potential to help millions of people who live with paralysis and neuropathy.

Many illnesses and injuries, including stroke, diabetes or spinal cord injury, can produce loss of touch, which makes everyday movements difficult and takes an emotional toll on patients. Imagine not being able to feel a hot cup or the hand holding yours. Previously, through brain-computer interface (BCI) technology, researchers have been able to electrically stimulate certain (gyral) areas of the brain and restore some sensation to the hand. Through this new research, scientists have successfully shown that stimulation of harder to reach (sulcal) areas of the brain using stereoelectroencephalography (SEEG) electrodes can evoke precise sensory percepts in the fingertips.

“From buttoning our shirts to holding a loved one’s hand, our sense of touch may be taken for granted until we lose it,” said the study’s co-principal investigator, Chad Bouton, professor in the Institute of Bioelectronic Medicine at the Feinstein Institutes. “These results show the ability to generate that sensation, even after it is lost, which may lead us to a clinical option in the future.”

Through a minimally invasive procedure led by neurosurgeon, associate professor in the Institute of Bioelectronic Medicine at the Feinstein Institutes and co-principal investigator on the study, Ashesh Mehta, MD, two patients were implanted with the SEEG electrodes in the sulci (grooves) of the brain. While providing electrical stimulation the study participants reported feelings of “tingling” or “sensation of electricity” localized to the hand and fingertips.

In a clinical study, brain implanted stereoelectroencephalography (SEEG) electrodes were used to evo

Restoring function with bioelectronic medicine

The Feinstein Institutes is the global scientific home of bioelectronic medicine, a field of research that combines molecular medicine, neuroscience and biomedical engineering to develop innovative therapies with the aim to treat diseases and conditions through targeted stimulation of nerves, including paralysis, arthritis, pulmonary hypertension and inflammatory bowel disease.

“Advances in artificial intelligence, brain electrodes and bioelectronic medicine hold significant promise for patients after spinal cord injury or stroke,” said Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes. “This remarkable study indicates bioelectronic medicine and neurosurgery could restore functions previously lost in these conditions.”

To research the brain’s response, the same electrodes used for stimulation were also used to record neural signals during mechanical stimulation of the hand. This process has allowed researchers to deepen the current knowledge of neural circuitry involved in processing touch-related sensations in the human brain, noted Santosh Chandrasekaran, Ph.D., investigator in the study and co-lead author on the paper with colleague Stephan Bickel, MD, Ph.D., also an investigator in the published study.

Recent biolectronic medicine progress at the Feinstein Institutes includes a published study around the most effective dose and time of day to stimulate the vagus nerve, a major nerve in the body that controls the body’s immune response.

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