Author: P. Shadbash & M. Maleknia

A hormone already known for curbing appetite and supporting weight loss may have a surprising second job: protecting the liver from inflammation and scarring. Researchers at McMaster University found that GDF15 activates a previously unknown brain-to-liver pathway that triggers the release of glucocorticoids, helping calm immune activity in the liver. Researchers at McMaster University have uncovered an unexpected role for a naturally occurring hormone already known for reducing appetite and…

Researchers have developed a new way to turn ordinary antibodies into tiny disease-fighting molecules that can work inside human cells, potentially opening new paths for treating Alzheimer’s, Parkinson’s, Huntington’s disease, and motor neurone disease. Researchers at the University of Essex have developed microscopic medicines that could pave the way for new approaches to treating neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and motor neurone disease (MND). Working with an international team,…

A widely prescribed blood pressure drug was associated with a 33% higher risk of serious kidney problems in people with type 2 diabetes, even when they were already taking kidney-protective medications. The surprising finding is prompting researchers to question whether DCCBs are always the safest second-line choice for diabetic kidney disease. New findings presented at the 63rd ERA Congress suggest that a commonly prescribed group of blood pressure drugs may…

Researchers have uncovered a surprising way triple-negative breast cancer may turn the body against itself. Tumors appear to recruit macrophages—immune cells normally involved in healing and fighting infection—and use them to release a protein called BDNF that draws nerves into the tumor. Those nerves may then help the cancer grow, resist treatment, and potentially spread. New research from the University of Oklahoma has revealed how an aggressive type of breast…

Researchers combined synthetic DNA with a semiconductor to create an ultra-low-power memory device capable of storing and processing information in the same place. The bio-hybrid technology could eventually help make AI systems and next-generation computers far more energy efficient. DNA serves as the genetic blueprint for every living organism, but it is also an extraordinarily dense way to store information. A single gram can hold about 215 million gigabytes of…

Gut microbes need something to eat, and when fiber is limited, they may begin consuming proteins from the mucus lining that protects the gut. Researchers found that fiber can suppress this process, while indigestible plant proteins help microbes produce more beneficial compounds. Plant based diets support health in several ways, including benefits for the gut, immune system, metabolism, and cardiovascular system. Part of that effect comes from encouraging a diverse…

Scientists have discovered that the aging human brain may be far less isolated from the rest of the body than once believed. Stanford researchers found that large numbers of immune cells from the blood begin entering the brain as early as middle age, where they can transform into microglia, the brain’s specialized immune cells. The finding overturns a long-standing assumption that these cells remain largely separate from the body’s immune…

A protein that evolved long before the human circulatory system may help unlock stronger cancer treatments. When C3 is produced inside tumors, it blocks immune-suppressing cells and gives immunotherapy a better chance to work. Researchers were even able to recreate this effect in resistant tumors, significantly improving survival in mice. An immune molecule that appeared in evolution long before blood circulation may help improve cancer immunotherapy. Scientists at Nagoya University…

Deep underground, bacteria may be capable of doing something remarkable: trapping toxic uranium before it spreads. When researchers fed microbes in uranium-contaminated mine water with glycerol, about 95% of the dissolved uranium disappeared within 130 days. The bacteria helped convert it into an unusually stable uranium compound that had rarely been observed before. Uranium, a radioactive heavy metal, is typically locked inside minerals in soil. However, mining and other environmental…

Stress may literally scramble the brain’s internal GPS. Researchers found that cortisol, a hormone released during stress, made people significantly worse at navigating a virtual environment and disrupted the precise activity of grid cells, specialized brain cells that help us understand where we are in space. When landmarks were missing, this navigation system nearly stopped functioning, while another brain region appeared to step in and compensate. Cortisol can scramble the…